TREATMENT OF PERIOCULAR INFANTILE CAPILLARY HAEMANGIOMA WITH ORAL PROPANOLOL, A CASE SERIES OF EIGHT CHILDREN.
Abstract
PURPOSE.   To study the efficacy of oral propranolol in the treatment of periocular infantile capillary haemangioma.
DESIGN.  Retrospective interventional case series.
PARTICIPANTS. Eight children presenting with PICH having visual axis occlusion, proptosis, cosmetic blemish or worry of the parents.
METHODS. All patients received oral propranolol at a dose of 2 mg/kg body weight/day in two divided doses. A complete systemic and ocular examination and serial photographs were taken before, during and after treatment.
RESULTS. Two patients lost to followup, five resolved fully. One patient developed drug reaction and discontinued treatment after good initial response.
CONCLUSION. Oral propranolol seems to be an effective drug for treatment of PICH with a good safety
KEY WORDS
Propranolol, Capillary haemangioma, Proptosis, Bradycardia
References
Haik BG, Karcioglu ZA, Gordon RA, Pechous BP. Capillary hemangioma (infantileperiocular hemangioma). Surv Ophthalmol 1994;38:399-426.
F Thommaze, C Leaute’ – Labreze’, J Colin. Efficacy of systemic propanolol for severe infantile hemangioma of the orbit and eyelid: a case study of eight patients. Br J Ophthalmol 2012;96:370-374.
Ahmed Awadein, Mohamed A Fakhry. Evaluation of Intralesional propranolol for periocular capillary hemangioma. Clinical Ophthalmology 2011:5 1135-1140.
Garza G, Fay A, Rubin PA. Treatment of pediatric vascular lesions of the eyelid and orbit. IntOphthalmolClin. 2001;41:43–55.
Wasserman BN, Medow NB, Homa-Palladino M, Hoehn ME. Treatmentof periocular capillary hemangiomas. J AAPOS. 2004; 8:175–181.
Ezekowitz RAB, Phil CBD, Muliken JB, Fokman J. Interferon alfa-2a therapy for life threatening hemangiomas of infancy. N Engl J Med.1992;326:1456–1463.
Fawcett SL, Grant I, Hall PN, et al. Vincristine as a treatment for a large haemangioma threatening vital functions. Br J Plast Surg. 2004;57:168–171.
Garden JM, Bakus AD, Paller AS. Treatment of cutaneous hemangiomasby the flashlamp-pumped pulsed dye laser: prospective analysis.J Pediatr. 1992;120:555–560.
Walker RS, Custer PL, Nerad JA. Surgical excision of periorbital capillary hemangiomas. Ophthalmology. 1994;101:1333–1340.
Le´aute´-Labre`ze C, Dumas de la Roque E, Hubiche T, et al. Propranolol for severe hemangiomas of infancy. New Engl J Med 2008;358:2650e1.
Downloads
Published
Issue
Section
License
OWNERSHIP OF COPYRIGHT
The copyright in this website and the material on this website (including without limitation the text, computer code, artwork, photographs, images, music, audio material, video material and audio-visual material on this website) is owned by OPHTHALMOLOGY PAKISTAN.
Â
COPYRIGHT LICENSE
OPHTHALMOLOGY PAKISTAN grants to you a worldwide non-exclusive royalty-free revocable license to:
a) view this website and the material on this website on a computer or mobile device via a web browser;
b) copy and store this website and the material on this website in your web browser cache memory; and
c) print pages from this website for your use.
d) OPHTHALMOLOGY PAKISTAN permits all published articles to be copied, redistributed, remixed, transmitted and the work be adapted provided the original work and source is appropriately cited.
OPHTHALMOLOGY PAKISTAN does not grant any other rights in relation to this website or the material on this website. In other words, all other rights are reserved.
For the avoidance of doubt, you must not adapt, edit, change, transform, publish, republish, distribute, redistribute, broadcast, rebroadcast or show or play in public this website or the material on this website (in any form or media) without appropriately and conspicuously citing the original work and source or OPHTHALMOLOGY PAKISTAN prior written permission.
Â
PERMISSIONS
You may request permission to use the copyright materials on this website by writing to chiefeditor@ophthalmologypakistan.com.
Â
ENFORCEMENT OF COPYRIGHT
OPHTHALMOLOGY PAKISTAN takes the protection of its copyright very seriously.
If OPHTHALMOLOGY PAKISTAN discovers that you have used its copyright materials in contravention of the license above, OPHTHALMOLOGY PAKISTAN may bring legal proceedings against you seeking monetary damages and an injunction to stop you using those materials. You could also be ordered to pay legal costs.
If you become aware of any use of OPHTHALMOLOGY PAKISTAN' copyright materials that contravenes or may contravene the license above, please report this by email to chiefeditor@ophthalmologypakistan.com.
Infringing material
If you become aware of any material on the website that you believe infringes your or any other person's copyright, please report this by email to chiefeditor@ophthalmologypakistan.com.
