COMPARISON OF ROLE OF PRE INJECTION TOPICAL ANTIBIOTIC AND PER OPERATIVE ONE DROP OF 5% POVIDONE-IODINE IN CONJUNCTIVAL SAC, BEFORE GIVING INTRA-VITREAL INJECTION OF ANTI-VEGF, IN PREVENTION AGAINST ACUTE ENDOPHTHALMITIS
Keywords:
Keywords, Topical Antibiotic, 5% Pyodine-Iodine, Avastin (Bevacizumab), Acute Endophthalmitus.Abstract
OBJECTIVE: To compare the role of the topical antibiotic course, 4 hourly for 1 day before intravitreal injection of Anti-VEGF and per-op one drop of 5% povidone-iodine solution in conjunctival sac just before injection, in prevention against endophthalmitis.
STUDY DESIGN: Randomized Controlled Trial
PLACE AND DURATION OF STUDY: Ophthalmology Department, DHQ Teaching Hospital, Gujranwala and Major Eye Clinic Centre, Gujranwala from January 2018, to June 2019.
METHODOLOGY: This trial was carried out on a total of 802 eyes for a duration of one and a half years. Patients presenting with indications for Intra-vitreal injection of Anti-VEGF to Eye OPD were included in the study. Patients were divided into two groups. Group-A401 eyes who received only one drop of 5% povidone-iodine solution in conjunctival sac just before intravitreal injection and Group-B 401 eyes did course of topical antibiotic (Moxifloxacin) for one day, before intravitreal injection of Anti-VEGF.
RESULTS: In group-A, there were 230(57.5%) were females and 171(42.5%) were males. In group-B, 240(60.0%) were females and 161(40.0%) were males. In group-A, no case of endophthalmitis was reported 0(0.00%) and in group-B as well 0(0.00%).
CONCLUSION: A drop of 5% povidone-iodine in conjunctival sac is sufficient to prevent endophthalmitis. There is no role of Topical antibiotic (Moxifloxacin) before intravitreal injections in the prevention against acute endophthalmitis.
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