Safety Profile and Efficacy of Intracameral Moxifloxacin for Endophthalmitis Prevention after Uncomplicated Phacoemulsification

Abstract

OBJECTIVE: To evaluate the incidence and safety profile of postoperative endophthalmitis in cases of uncomplicated phacoemulsification with intracameral injection of moxifloxacin.  

METHODOLOGY: This was a single-centered observational study conducted at the eye department, College of Medicine and Dentistry, FMH, Lahore. All patients underwent uncomplicated phacoemulsification with foldable intraocular lens implant under local anaesthesia. This was followed by intracameral injection of moxifloxacin (0.5mg/0.1ml) at the end of surgery. Prior Ethical approval was obtained from FMH IRB. Wilcoxon Signed Rank was applied to compare pre- and post-operatively visual acuity in patients.

RESULTS: In this study, 101 patients, 54 females (53.5%) and 47 males (46.5%) were included. The average age of patients was 55.38±8.10 years. Among 101 patients, 94 (93.1%) of the patients' corneas were clear, and 7 (6.9%) of the patients had microcysts. Endothelial cell count was measured in patients preoperatively and postoperatively; it was lower postoperatively, and statistical results demonstrated a highly significant difference between pre-operative and post-operative values (p < 0.001).

CONCLUSION: The study results showed that the UCVA improved from day 1 to day 30, with no evidence of postoperative endophthalmitis in cases of uncomplicated phacoemulsification. Endothelial cell count was minimally decreased postoperatively.