TREATMENT OF PERIOCULAR INFANTILE CAPILLARY HAEMANGIOMA WITH ORAL PROPANOLOL, A CASE SERIES OF EIGHT CHILDREN.

Muhammad Ramzan, Waqar Ahmed, Iftikhar Ahmed

Abstract


PURPOSE.    To study the efficacy of oral propranolol in the treatment of periocular infantile capillary haemangioma.

DESIGN.   Retrospective interventional case series.

PARTICIPANTS. Eight children presenting with PICH having visual axis occlusion, proptosis, cosmetic blemish or worry of the parents.

METHODS. All patients received oral propranolol at a dose of 2 mg/kg body weight/day in two divided doses. A complete systemic and ocular examination and serial photographs were taken before, during and after treatment.

RESULTS. Two patients lost to followup, five resolved fully. One patient developed drug reaction and discontinued treatment after good initial response.

CONCLUSION. Oral propranolol seems to be an effective drug for treatment of PICH with a good safety

KEY WORDS

Propranolol, Capillary haemangioma, Proptosis, Bradycardia


Full Text:

PDF

References


Haik BG, Karcioglu ZA, Gordon RA, Pechous BP. Capillary hemangioma (infantileperiocular hemangioma). Surv Ophthalmol 1994;38:399-426.

F Thommaze, C Leaute’ – Labreze’, J Colin. Efficacy of systemic propanolol for severe infantile hemangioma of the orbit and eyelid: a case study of eight patients. Br J Ophthalmol 2012;96:370-374.

Ahmed Awadein, Mohamed A Fakhry. Evaluation of Intralesional propranolol for periocular capillary hemangioma. Clinical Ophthalmology 2011:5 1135-1140.

Garza G, Fay A, Rubin PA. Treatment of pediatric vascular lesions of the eyelid and orbit. IntOphthalmolClin. 2001;41:43–55.

Wasserman BN, Medow NB, Homa-Palladino M, Hoehn ME. Treatmentof periocular capillary hemangiomas. J AAPOS. 2004; 8:175–181.

Ezekowitz RAB, Phil CBD, Muliken JB, Fokman J. Interferon alfa-2a therapy for life threatening hemangiomas of infancy. N Engl J Med.1992;326:1456–1463.

Fawcett SL, Grant I, Hall PN, et al. Vincristine as a treatment for a large haemangioma threatening vital functions. Br J Plast Surg. 2004;57:168–171.

Garden JM, Bakus AD, Paller AS. Treatment of cutaneous hemangiomasby the flashlamp-pumped pulsed dye laser: prospective analysis.J Pediatr. 1992;120:555–560.

Walker RS, Custer PL, Nerad JA. Surgical excision of periorbital capillary hemangiomas. Ophthalmology. 1994;101:1333–1340.

Le´aute´-Labre`ze C, Dumas de la Roque E, Hubiche T, et al. Propranolol for severe hemangiomas of infancy. New Engl J Med 2008;358:2650e1.