Comparison between 0.5% Timolol Maleate and 0.2% Brimonidine Tartrate in controlling increase in intraocular pressure after Neodymium: Yttrium-Aluminium-Garnet laser iridotomy.

Abstract

AIM: To compare the effectiveness of prophylactically given 0.5% Timolol maleate and 0.2% Brimonidine tartrate in controlling the increase of intraocular pressure after Nd:YAG laser iridotomy.

MATERIALS AND METHODS: 70 patients in two equal groups were studied at Department of Ophthalmology, Jinnah Hospital, Lahore from 01-07-2011 to 31-12-2012. It was a Quasi-experimental study, non–probability purposive sampling was done. Group A was an experimental group which received 0.2% Brimonidine tartrate and group B was control group which received 0.5% Timolol maleate 1 hour before the laser treatment.

RESULTS: In our study the mean age was calculated to be 46.38 ± 7.56 years, out of 70 patients, male patients were 54.29% (n=19) in Group-A and 60% (n=21) in Group-B, while female patients were 45.71% (n=16) in Group-A and 40% (n=14) in Group-B, mean intraocular pressure was recorded as 20.54 ± 2.43 in Group-A and 18.31 ± 2.15 in Group-B respectively, comparison of effectiveness in both groups was recorded as 34.29% (n=12) in Group-A and 71.43% (n=25) in Group-B. 65.22% (n=23) in Group-A and 28.57% (n=10) in Group-B did not show efficacy, p value was calculated as 0.002 which shows significant difference in both groups.

CONCLUSION: We concluded that 0.5% Timolol maleate is more effective than 0.2% Brominidine tartrate in controlling increase in intraocular pressure following Nd:YAG laser iridotomy.

KEYWORDS: Intra ocular pressure, Nd:YAG laser iridotomy, 0.5% Timolol maleate, 0.2% Brimonidine tartrate.